The Malawi Institute of Technology (MIT) is the first school at MUST to be operationalized in 2014 and for a year, it operated with one department, the Basic Sciences Department. All academic staff members, irrespective of their areas of specialisation, belonged to this department in the 2014/15 academic year.

The School is currently headed by an Executive Dean, Dr Michael Zimba. He is the second ED for the school since inception. Under the ED are heads of department for Applied Studies (Dr Peter Mwantobe), Computer Studies and Information Technology (Dr Bennett Kankuzi), and Engineering (Dr Richard Nkhoma).

In 2014, the MIT started with three Engineering programmes at undergraduate level and two postgraduate programmes. The number of undergraduate programmes has since grown to 10 while the number of postgraduate programmes has also grown to 11.

The MIT academic programmes are Bachelor of Engineering (BEng) in Biomedical Engineering (Hons), BEng in Chemical Engineering (Hons), BEng in Manufacturing Engineering (Hons), BEng in Metallurgy and Materials Engineering (Hons), BEng in Polymer and Textile Engineering (Hons), BSc in Computer Systems and Security, BSc in Business Information Technology, BSc in Sciences Education, BSc in Food Science and Technology, and BSc in Mathematical Sciences. The PG programmes are MSc in Data Science, MSc in Computer Science, MSc in Information Technology, MSc in Innovation, MSc in Entrepreneurship, MSc in Mathematical Modelling, MBA in Strategic Family Business, MBA in Business Leadership, PhD in Innovation and Development, PhD in Business Leadership and PhD in Applied Mathematics.  

In line with the vision and mission of the mother university, the MIT is establishing and positioning itself as the centre of excellence in science, technology, innovation and entrepreneurship education, training and research through provision of a healthy teaching, learning and research environment grounded well in the principles of science and technology, promoting creativity, and nurturing teamwork.

The School recently established the Centre for Artificial Intelligence and STEAM (Science, Technology, Engineering, Arts, and Mathematics), abbreviated as CAIST.